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1 article(s) from Runtsch, Leander Simon

Azobenzene-based inhibitors of human carbonic anhydrase II

Leander Simon Runtsch,
David Michael Barber,
Peter Mayer,
Michael Groll,
Dirk Trauner and
Johannes Broichhagen

Beilstein J. Org. Chem. 2015, 11, 1129–1135, doi:10.3762/bjoc.11.127

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Figure 1: Function and inhibition of hCAII. a) hCAII (pdb: 2vva [7]) catalyzes the hydration of carbon dioxide t...

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Scheme 1: Synthesis and characterization of azobenzene-containing aryl sulfonamides by different strategies. ...

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Figure 2: Crystal structures for compounds 1a–i (co-solvents and/or multiple molecules in the asymmetric cell...

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Figure 3: Crystal structure of hCAII bound to 1d (pdb: 5byi). a) The terminal amine of 1d is solvent-exposed,...

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Figure 4: Inhibition of hCAII by electronically different azobenzene sulfonamides and AAZ. a) Endpoint measur...

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Published 07 Jul 2015

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